Correction: MicroRNA Regulation and Tissue-Specific Protein Interaction Network
نویسندگان
چکیده
منابع مشابه
MicroRNA Regulation and Tissue-Specific Protein Interaction Network
BACKGROUND 'Fine-tuning' of protein abundance makes microRNAs (miRNAs) pervasively implicated in human biology. Although targeting many mRNAs endows the power of single miRNA to regulate complex biological processes, its functional roles in a particular tissue will be inevitably restricted because only a subset of its target genes is expressed. METHODS Here, we analyze the characteristics of ...
متن کاملConstruction and Analysis of Tissue-Specific Protein-Protein Interaction Networks in Humans
We have studied the changes in protein-protein interaction network of 38 different tissues of the human body. 123 gene expression samples from these tissues were used to construct human protein-protein interaction network. This network is then pruned using the gene expression samples of each tissue to construct different protein-protein interaction networks corresponding to different studied ti...
متن کاملMicroRNA regulation of human protein protein interaction network.
Since the functional state of a protein-protein interaction network depends on gene expression, a fundamental question is what relationships exist between protein interaction network and gene regulation. In particular, microRNAs have recently emerged as a major class of post-transcriptional regulators that influences a large proportion of genes in higher eukaryotes. Here we show that protein co...
متن کاملconstruction and analysis of tissue-specific protein-protein interaction networks in humans
we have studied the changes in protein-protein interaction network of 38 different tissues of the human body. 123 gene expression samples from these tissues were used to construct human protein-protein interaction network. this network is then pruned using the gene expression samples of each tissue to construct different protein-protein interaction networks corresponding to different studied ti...
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Osteoarthritis is the most common form of arthritis among elderly adults. Herein, we performed protein-protein interaction (PPI) and miRNA network analysis to evaluate the global correlation between miRNA regulation and the PPI network in human osteoarthritis. Our results showed that desmoplakin (DSP), cystatin A (CSTA), calmodulin 1, tyrosine kinase endothelial, insulin-like growth factor 1 (I...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2011
ISSN: 1932-6203
DOI: 10.1371/annotation/60addd69-bd2d-4ecf-8369-6a5a1bf2cd04